TRFolder: A Utility Software for Telomerase RNA Structure Prediction


TRFolder is a utility program capable of searching for the core structure (including pseudoknots and triple helices) of telomerase RNAs. It consists of a set of functions for telomerase RNA (TR) specific structure prediction. Unlike existing general purpose structure prediction programs, TRFolder works progressively to predict core TR elements pseudoknots, triple helices, telomere repeat template boundary elements, and core-closing stems that occur in TRs.


TRFolder is coded in C with a GUI implemented with Python. C compiler version: Dev-Cpp ( and python compiler version: python 2.5.1 ( The TRFolder package has been compiled and tested on Windows platforms.


This package is for windows platforms (vista and xp). The package contains TRFolder program and GUI; README contains installation and usage instructions. Released February, 2009. Updated February, 2012.


    [Guo et al., 2011] Guo, L., Zhang, D., Wang, Y., Malmberg, R., McEachern, M., and Cai, L. (2010) TRFolder: Computational prediction of novel telomerase RNAs in yeast genomes, Journal of Bioinformatics Research and Applications, Vol. 7, No. 1, 63-81.